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Significance, detection and markers of disseminated breast cancer cells

The development of distant metastases is the major cause of these deaths. According to a longstanding hypothesis, breast cancer dissemination should involve a succession of clinical and pathological stages starting with carcinoma in situprogressing into invasive lesion and culminating in metastatic disease. Moreover, it was thought for decades that metastasizing breast cancer cells BCC first disseminated to the lymph nodes LN before reaching peripheral blood PB and distant locations, including bone marrow BM.

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