Breast cancer causing hormones


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A sweeping new analysis adds to the evidence that many women who take hormone therapy during menopause are more likely to develop breast cancer — and remain at higher risk of cancer for more than a decade after they stop taking the drugs. The study, published Thursday in the Lancetlooked at data from dozens of studies, including long-term data on more thanwomen who developed breast cancer after menopause. The longer women took the medicine, the more likely they were to develop breast cancer.

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Hormone Balance: The Key to Breast Cancer Prevention

The incidence of breast cancer in women varies with age, mammary gland mass and exposure to endogenous and exogenous hormones. Hormonal influences that affect growth of the mammary gland increase the risk of breast cancer; for example earlier menarche and later menopause. Childbearing protects against later development of breast cancer, and breastfeeding further decreases the risk.

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Hormone Therapy and Breast Cancer: Yes, There Is Risk

Why does breast cancer sometimes recur after treatment? A new study suggests that in part, the answer may lie in the effect of adjuvant hormone therapy on some cancer cells. Magnani and colleagues from Imperial College London, the University of Milan in Italy, and Yonsei University College of Medicine in Seoul, South Korea — among other academic institutions — have recently delved into this debate, studying approximately 50, single cells of human breast cancer.

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Estrogens, a group of female sex hormones, are known human carcinogens. Although these hormones have essential physiological roles in both females and males, they have also been associated with an increased risk of certain cancers. Menopausal hormone therapy with estrogen alone increases the risk of endometrial cancer and is used only in women who have had a hysterectomy.